Longevity / cellular researchPreclinical (animal) evidence

MOTS-C (PS-403)

A research guide to MOTS-C: what the published literature covers, how it is characterized, and how to reconstitute, store, and verify it. Written as research framing, never usage guidance.

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Overview

Longevity and cellular-research compounds are studied for pathways such as mitochondrial signaling, telomere biology, and redox balance, mostly in preclinical work. Some rest on a limited, single-group literature. Where that is the case, this guide says so rather than overstating it.

A mitochondrial-derived peptide studied for metabolic regulation and exercise-mimetic signaling.

Evidence at a glance: Preclinical (animal) evidence

The cited evidence here is preclinical animal-model work, with limited or no human-trial data. Read the research profile accordingly.

Molecular identity

Molecular formula
C101H152N28O23S2
Molecular weight
2174.5 g/mol
CAS number
1627580-64-6
Amino acids
16
Appearance
White lyophilized powder
Purity (HPLC)
98.9%

Researched mechanism

Studied for AMPK activation and metabolic-stress signaling as a mitochondrial-derived peptide.

Described as a mechanism characterized in the literature, not an effect you should expect from use.

What the published research shows

  • Metabolic and exercise-mimetic effects in preclinical models.

    animal modelrodent metabolic models·Lee et al., 2015 (representative)PubMed ↑

Honest note on evidence: Evidence is preclinical.

Every citation states its study type and population, so preclinical data is never presented as human-efficacy evidence.

How it compares

VersusAttributeNote
NAD+FocusBoth are studied in mitochondrial/energy-metabolism research.

Reconstitution

Concentration math only: adding bacteriostatic water to the vial gives the resulting mg/mL shown below. This is not usage guidance.

VialBacteriostatic waterConcentration
10 mg2 mL5 mg/mL
20 mg2 mL10 mg/mL
40 mg2 mL20 mg/mL
Open the reconstitution calculator →

Storage & stability

StateTemperatureDuration
Lyophilized (unopened)-20°C24 months
Reconstituted2–8°Cup to 4 weeks

Common questions

What is a mitochondrial-derived peptide?+

A peptide encoded within mitochondrial DNA; MOTS-c is one of the best-known research examples.

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